<?xml version="1.0" encoding="UTF-8"?>
<urlset xmlns="http://www.sitemaps.org/schemas/sitemap/0.9" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.w3.org/1999/xhtml http://www.w3.org/2002/08/xhtml/xhtml1-strict.xsd" xmlns:xhtml="http://www.w3.org/1999/xhtml" xmlns:video="http://www.google.com/schemas/sitemap-video/1.1"><url><loc>https://www.alphanate.com/en/-/learn-more-about-hemophilia-a</loc><lastmod>2025-07-10T14:22:14+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/-/learn-more-about-hemophilia-a" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/-/learn-more-about-hemophilia-a"/></url><url><loc>https://www.alphanate.com/en/-/hemophilia-myths-and-facts</loc><lastmod>2021-03-16T12:35:24+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/-/hemophilia-myths-and-facts" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/-/hemophilia-myths-and-facts"/></url><url><loc>https://www.alphanate.com/en/-/tips-for-living-well-with-hemophilia-a</loc><lastmod>2025-07-10T14:25:07+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/-/tips-for-living-well-with-hemophilia-a" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/-/tips-for-living-well-with-hemophilia-a"/></url><url><loc>https://www.alphanate.com/en/-/using-the-activity-risk-scale-to-help-plan-your-activities</loc><lastmod>2017-10-11T17:38:18+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/-/using-the-activity-risk-scale-to-help-plan-your-activities" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/-/using-the-activity-risk-scale-to-help-plan-your-activities"/></url><url><loc>https://www.alphanate.com/en/-/managing-bleeds-an-important-part-of-living-with-hemophilia-a</loc><lastmod>2025-07-10T14:27:27+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/-/managing-bleeds-an-important-part-of-living-with-hemophilia-a" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/-/managing-bleeds-an-important-part-of-living-with-hemophilia-a"/></url><url><loc>https://www.alphanate.com/en/-/learn-more-about-your-von-willebrand-disease</loc><lastmod>2025-07-10T14:30:51+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/-/learn-more-about-your-von-willebrand-disease" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/-/learn-more-about-your-von-willebrand-disease"/></url><url><loc>https://www.alphanate.com/en/-/learn-more-about-living-with-von-willebrand-disease</loc><lastmod>2025-07-10T14:28:40+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/-/learn-more-about-living-with-von-willebrand-disease" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/-/learn-more-about-living-with-von-willebrand-disease"/></url><url><loc>https://www.alphanate.com/en/-/using-the-activity-risk-scale-to-help-plan-your-activiti-1</loc><lastmod>2017-10-11T17:38:08+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/-/using-the-activity-risk-scale-to-help-plan-your-activiti-1" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/-/using-the-activity-risk-scale-to-help-plan-your-activiti-1"/></url><url><loc>https://www.alphanate.com/en/-/managing-bleeds-an-important-part-of-living-with-vwd</loc><lastmod>2025-07-10T14:29:46+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/-/managing-bleeds-an-important-part-of-living-with-vwd" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/-/managing-bleeds-an-important-part-of-living-with-vwd"/></url><url><loc>https://www.alphanate.com/en/</loc><lastmod>2026-02-18T10:46:13+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/"/></url><url><loc>https://www.alphanate.com/en/landing1</loc><lastmod>2026-02-18T10:46:13+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/landing1" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/landing1"/></url><url><loc>https://www.alphanate.com/en/page-not-found</loc><lastmod>2026-02-18T10:46:14+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/page-not-found" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/page-not-found"/></url><url><loc>https://www.alphanate.com/en/hcp</loc><lastmod>2026-02-18T10:46:16+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp"/></url><url><loc>https://www.alphanate.com/en/hcp/contact-us</loc><lastmod>2026-02-18T10:46:16+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/contact-us" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/contact-us"/></url><url><loc>https://www.alphanate.com/en/hcp/support</loc><lastmod>2026-02-18T10:46:16+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/support" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/support"/></url><url><loc>https://www.alphanate.com/en/hcp/about-grifols</loc><lastmod>2026-02-18T10:46:16+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/about-grifols" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/about-grifols"/></url><url><loc>https://www.alphanate.com/en/hcp/thank-you</loc><lastmod>2026-02-18T10:46:17+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/thank-you" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/thank-you"/></url><url><loc>https://www.alphanate.com/en/hcp/sign-up</loc><lastmod>2026-02-18T10:46:17+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/sign-up" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/sign-up"/></url><url><loc>https://www.alphanate.com/en/hcp/search-results</loc><lastmod>2026-02-18T10:46:17+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/search-results" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/search-results"/></url><url><loc>https://www.alphanate.com/en/hcp/privacy-policy</loc><lastmod>2026-02-18T10:46:17+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/privacy-policy" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/privacy-policy"/></url><url><loc>https://www.alphanate.com/en/cookies-policy</loc><lastmod>2026-02-18T10:46:17+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/cookies-policy" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/cookies-policy"/></url><url><loc>https://www.alphanate.com/en/patients/support-and-resources</loc><lastmod>2026-02-18T10:46:18+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/support-and-resources" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/support-and-resources"/></url><url><loc>https://www.alphanate.com/en/patients/support-and-resources/factors-for-health</loc><lastmod>2026-02-18T10:46:19+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/support-and-resources/factors-for-health" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/support-and-resources/factors-for-health"/><video:video><video:title>Easy Reconstitution and Administration</video:title><video:player_loc>http://players.brightcove.net/1971571407001/default_default/index.html?videoId=6311935377112</video:player_loc></video:video><video:video><video:title>Storing and infusing ALPHANATE</video:title><video:description>ALPHANATE is for intravenous use only after reconstitution. Use plastic disposable syringes. Do not refrigerate after reconstitution. Reconstituted ALPHANATE may be stored at room temperature (not to exceed 30°C) prior to administration, but administer intravenously within 3 hours. Discard any unused contents into an appropriate safety container. Do not administer ALPHANATE at a rate exceeding 10 mL/min.</video:description><video:player_loc>http://players.brightcove.net/1971571407001/default_default/index.html?videoId=</video:player_loc></video:video></url><url><loc>https://www.alphanate.com/en/patients/support-and-resources/hemophilia-doctor-discussion-guide</loc><lastmod>2026-02-18T10:46:19+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/support-and-resources/hemophilia-doctor-discussion-guide" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/support-and-resources/hemophilia-doctor-discussion-guide"/></url><url><loc>https://www.alphanate.com/en/patients/support-and-resources/hemophilia-resources-and-links</loc><lastmod>2026-02-18T10:46:19+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/support-and-resources/hemophilia-resources-and-links" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/support-and-resources/hemophilia-resources-and-links"/><video:video><video:title>ALPHANATE Manufacturing Process</video:title><video:description>Since 1997, there has never been a confirmed case of pathogen or prion transmission with ALPHANATE</video:description><video:player_loc>http://players.brightcove.net/1971571407001/default_default/index.html?videoId=2698886779001</video:player_loc></video:video></url><url><loc>https://www.alphanate.com/en/patients</loc><lastmod>2026-02-18T10:46:22+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients"/></url><url><loc>https://www.alphanate.com/en/patients/living-with-hemophilia</loc><lastmod>2026-02-19T06:47:31+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/living-with-hemophilia" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/living-with-hemophilia"/></url><url><loc>https://www.alphanate.com/en/patients/living-with-vwd</loc><lastmod>2026-02-19T06:47:31+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/living-with-vwd" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/living-with-vwd"/></url><url><loc>https://www.alphanate.com/en/patients/about-grifols</loc><lastmod>2026-02-18T10:46:38+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/about-grifols" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/about-grifols"/></url><url><loc>https://www.alphanate.com/en/patients/sign-up</loc><lastmod>2026-02-18T10:46:39+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/sign-up" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/sign-up"/></url><url><loc>https://www.alphanate.com/en/patients/contact-us</loc><lastmod>2026-02-18T10:46:40+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/contact-us" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/contact-us"/></url><url><loc>https://www.alphanate.com/en/patients/thank-you</loc><lastmod>2026-02-18T10:46:45+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/thank-you" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/thank-you"/></url><url><loc>https://www.alphanate.com/en/patients/search-results</loc><lastmod>2026-02-18T10:46:45+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/search-results" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/search-results"/></url><url><loc>https://www.alphanate.com/en/patients/privacy-policy</loc><lastmod>2026-02-18T10:46:46+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/privacy-policy" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/privacy-policy"/></url><url><loc>https://www.alphanate.com/en/patients/about</loc><lastmod>2026-02-18T10:46:21+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/about" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/about"/><video:video><video:title>About Grifols</video:title><video:description>Learn more about Grifols</video:description><video:player_loc>http://players.brightcove.net/1971571407001/default_default/index.html?videoId=3682340560001</video:player_loc></video:video></url><url><loc>https://www.alphanate.com/en/patients/about/what-is-alphanate</loc><lastmod>2026-02-18T10:46:47+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/about/what-is-alphanate" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/about/what-is-alphanate"/></url><url><loc>https://www.alphanate.com/en/patients/about/why-alphanate-hemophilia-treatment</loc><lastmod>2026-02-18T10:46:49+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/about/why-alphanate-hemophilia-treatment" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/about/why-alphanate-hemophilia-treatment"/><video:video><video:title>Grifols is committed to safety before, during, and after ALPHANATE manufacturing</video:title><video:player_loc>http://players.brightcove.net/1971571407001/default_default/index.html?videoId=</video:player_loc></video:video></url><url><loc>https://www.alphanate.com/en/patients/about/alphanate-dosing</loc><lastmod>2026-02-18T10:46:50+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/about/alphanate-dosing" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/about/alphanate-dosing"/></url><url><loc>https://www.alphanate.com/en/patients/about/bleeding-disorders-patient-support-and-resources</loc><lastmod>2026-02-18T10:46:20+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/about/bleeding-disorders-patient-support-and-resources" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/about/bleeding-disorders-patient-support-and-resources"/></url><url><loc>https://www.alphanate.com/en/hcp/safety</loc><lastmod>2026-02-18T10:46:51+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/safety" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/safety"/><video:video><video:title>ALPHANATE provides natural protection through its FVIII/VWF complex</video:title><video:description>About ALPHANATE: A hemophilia A and von Willebrand disease treatment
Role of FVIII/VWF complex</video:description><video:player_loc>http://players.brightcove.net/1971571407001/default_default/index.html?videoId=2698826475001</video:player_loc></video:video></url><url><loc>https://www.alphanate.com/en/hcp/safety/plasma-donation-process</loc><lastmod>2026-02-18T10:46:52+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/safety/plasma-donation-process" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/safety/plasma-donation-process"/></url><url><loc>https://www.alphanate.com/en/alphanate-manufacturing-process</loc><lastmod>2026-02-18T10:46:54+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/alphanate-manufacturing-process" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/alphanate-manufacturing-process"/></url><url><loc>https://www.alphanate.com/en/hcp/safety/alphanate-quality-control</loc><lastmod>2026-02-18T10:46:25+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/safety/alphanate-quality-control" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/safety/alphanate-quality-control"/></url><url><loc>https://www.alphanate.com/en/patients/living-with-hemophilia-entry</loc><lastmod>2026-04-02T06:47:32+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/living-with-hemophilia-entry" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/living-with-hemophilia-entry"/><video:video><video:title>So why give both factors together?</video:title><video:description>Watch how circulating FVIII is quickly inactivated by a variety of proteases when it travels without the protection of VWF.</video:description><video:player_loc>http://players.brightcove.net/1971571407001/default_default/index.html?videoId=2698772107001</video:player_loc></video:video><video:video><video:title>What is ALPHANATE?</video:title><video:description>Now, watch how the FVIII travels when it is bound to VWF.</video:description><video:player_loc>http://players.brightcove.net/1971571407001/default_default/index.html?videoId=#</video:player_loc></video:video></url><url><loc>https://www.alphanate.com/en/patients/safety</loc><lastmod>2026-02-18T10:46:55+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/safety" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/safety"/></url><url><loc>https://www.alphanate.com/en/patients/safety/alphanate-plasma-donation-process</loc><lastmod>2026-02-18T10:46:32+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/safety/alphanate-plasma-donation-process" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/safety/alphanate-plasma-donation-process"/></url><url><loc>https://www.alphanate.com/en/patients/safety/alphanate-manufacturing-process</loc><lastmod>2026-02-18T10:46:55+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/safety/alphanate-manufacturing-process" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/safety/alphanate-manufacturing-process"/></url><url><loc>https://www.alphanate.com/en/patients/living-with-vwd-entry</loc><lastmod>2026-04-02T06:47:32+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/patients/living-with-vwd-entry" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/patients/living-with-vwd-entry"/></url><url><loc>https://www.alphanate.com/en/hcp/about</loc><lastmod>2026-02-18T10:46:57+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/about" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/about"/></url><url><loc>https://www.alphanate.com/en/hcp/about/alphanate-clinical-trial-data</loc><lastmod>2026-02-18T10:46:59+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/about/alphanate-clinical-trial-data" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/about/alphanate-clinical-trial-data"/></url><url><loc>https://www.alphanate.com/en/hcp/pharmacokinetic-profile-of-alphanate</loc><lastmod>2026-02-18T10:47:00+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/pharmacokinetic-profile-of-alphanate" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/pharmacokinetic-profile-of-alphanate"/></url><url><loc>https://www.alphanate.com/en/hcp/about/plasma-derived-product-properties</loc><lastmod>2026-02-18T10:47:01+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/about/plasma-derived-product-properties" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/about/plasma-derived-product-properties"/></url><url><loc>https://www.alphanate.com/en/hcp/about/alphanate-storage-administration-and-design</loc><lastmod>2026-02-18T10:47:03+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/about/alphanate-storage-administration-and-design" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/about/alphanate-storage-administration-and-design"/></url><url><loc>https://www.alphanate.com/en/hcp/about/ordering-alphanate</loc><lastmod>2026-02-18T10:46:44+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/about/ordering-alphanate" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/about/ordering-alphanate"/></url><url><loc>https://www.alphanate.com/en/hcp/support/factors-for-health</loc><lastmod>2026-02-18T10:47:04+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/support/factors-for-health" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/support/factors-for-health"/></url><url><loc>https://www.alphanate.com/en/hcp/support/living-with-hemophilia-and-vwd</loc><lastmod>2026-02-18T10:46:44+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/support/living-with-hemophilia-and-vwd" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/support/living-with-hemophilia-and-vwd"/></url><url><loc>https://www.alphanate.com/en/hcp/support/hemophilia-and-vwd-resources</loc><lastmod>2026-02-18T10:47:04+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/support/hemophilia-and-vwd-resources" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/support/hemophilia-and-vwd-resources"/></url><url><loc>https://www.alphanate.com/en/hcp/dosing-and-costs</loc><lastmod>2026-02-18T10:47:06+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/dosing-and-costs" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/dosing-and-costs"/></url><url><loc>https://www.alphanate.com/en/hcp/dosing-and-costs/hemophilia-a</loc><lastmod>2026-02-18T10:47:07+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/dosing-and-costs/hemophilia-a" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/dosing-and-costs/hemophilia-a"/></url><url><loc>https://www.alphanate.com/en/hcp/dosing-and-costs/von-willebrand-disease</loc><lastmod>2026-02-18T10:47:07+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/dosing-and-costs/von-willebrand-disease" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/dosing-and-costs/von-willebrand-disease"/></url><url><loc>https://www.alphanate.com/en/hcp/dosing-and-costs/wapps-hemo</loc><lastmod>2026-02-18T10:47:08+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/dosing-and-costs/wapps-hemo" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/dosing-and-costs/wapps-hemo"/><video:video><video:title>Individualized Dosing - Videos</video:title><video:description>WAPPS-Hemo: Overview, Adult case study and Pediatric case study</video:description><video:player_loc>http://players.brightcove.net/1971571407001/default_default/index.html?videoId=6329410685112</video:player_loc></video:video></url><url><loc>https://www.alphanate.com/en/hcp/request-a-representative</loc><lastmod>2026-02-18T10:47:09+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/request-a-representative" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/request-a-representative"/></url><url><loc>https://www.alphanate.com/en/hcp/request-a-representative/thank-you</loc><lastmod>2026-02-18T10:47:09+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/request-a-representative/thank-you" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/request-a-representative/thank-you"/></url><url><loc>https://www.alphanate.com/en/inscription-form</loc><lastmod>2026-02-18T10:47:09+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/inscription-form" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/inscription-form"/></url><url><loc>https://www.alphanate.com/en/thank-you</loc><lastmod>2026-02-18T10:47:10+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/thank-you" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/thank-you"/></url><url><loc>https://www.alphanate.com/en/unsubscribe</loc><lastmod>2026-02-18T10:47:10+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/unsubscribe" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/unsubscribe"/></url><url><loc>https://www.alphanate.com/en/hcp/alphanate-dosing/alphanate-cost-calculator/cost-calculator-alphanate-vwd</loc><lastmod>2026-02-18T10:47:10+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/alphanate-dosing/alphanate-cost-calculator/cost-calculator-alphanate-vwd" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/alphanate-dosing/alphanate-cost-calculator/cost-calculator-alphanate-vwd"/></url><url><loc>https://www.alphanate.com/en/hcp/alphanate-dosing/alphanate-cost-calculator/cost-calculator-alphanate-sd</loc><lastmod>2026-02-18T10:47:10+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/alphanate-dosing/alphanate-cost-calculator/cost-calculator-alphanate-sd" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/alphanate-dosing/alphanate-cost-calculator/cost-calculator-alphanate-sd"/></url><url><loc>https://www.alphanate.com/en/hcp/alphanate-dosing/alphanate-cost-calculator/cost-calculator-alphanine</loc><lastmod>2026-02-18T10:47:10+00:00</lastmod><changefreq>daily</changefreq><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" href="https://www.alphanate.com/en/hcp/alphanate-dosing/alphanate-cost-calculator/cost-calculator-alphanine" hreflang="en-US" rel="alternate"/><xhtml:link xmlns:xhtml="http://www.w3.org/TR/xhtml11/xhtml11_schema.html" rel="alternate" hreflang="x-default" href="https://www.alphanate.com/en/hcp/alphanate-dosing/alphanate-cost-calculator/cost-calculator-alphanine"/></url></urlset>